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It may also impact other neurotransmitters like dopamine (which plays a role in pleasure, motivation, and learning) but thats not clear right now, says Christoph Buettner, M.D., Ph.D., chief of the division of endocrinology at Rutgers Robert Wood Johnson Medical School

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8 Topiramate side effects and health risks Topiramate use for weight loss can cause many adverse effects, such as: 1,2 Nervousness Drowsiness Numbness in feet or hands Shaking or tremors Nausea, stomach pain, and constipation Excessive menstrual bleeding Missed menstrual periods Bone pain Weight loss Serious side effects may include: 1,2 Hyperthermia Suicidal ideation Impaired liver function and liver disease Bloody or cloudy urine Painful urination Usual bruising or bleeding Intense side or back pain Fever If you experience any troubling side effects of topiramate or an unusual or allergic reaction, call your doctor immediately

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Clinical Obesity, 9(5), e12312