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Patients with uncontrolled AH also exhibit elevated intracellular Ca 2+ levels [304], although these authors did not investigate the potential role of oxidative damage or eryptosis in this context
Outcomes included change from baseline at week 40 in HbA1c (primary outcome) and bodyweight (secondary confirmatory outcome), evaluated through trial product estimand (no treatment discontinuation or without rescue medication) and treatment policy estimand (regardless of treatment discontinuation or rescue medication) strategies
[47] Phase III trials commenced in January 2007, [48] and completed 2009 [49] with preliminary results released in December 2009
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