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Indeed, it is puzzling why only IGLE neurons detecting intestinal distention induce satiation, while mucosal ending VANs that contain gut peptide receptors and are ideally situated in close proximity to EECs would not be involved in metabolic homeostasis
A 2024 clinical study found that those who exercised and took GLP-1s like Ozempic kept weight off better and regained less weight when they stopped taking GLP-1s compared to those who didnt exercise
For example, studies using radiolabeled exenatide have shown that it can readily enter the mouse brain, though this central uptake appears to diminish at higher doses (Kastin and Akerstrom, 2003)
[DOI] [PubMed] [Google Scholar] 54.Gujral J.S., Knight T.R., Farhood A., Bajt M.L., Jaeschke H
But first our audience is resourceful, and a lot of them have already been doing their own research
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