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Oncogene 37 , 50075019 (2018)

This guarantees reliable experimental performance across a range of applications, from mechanism-of-action studies to therapeutic development and screening of next-generation metabolic drugs

In order to set the system in motion, a stimulus must drive a physiological parameter beyond its normal range (that is, beyond homeostasis)

Thus, as circulating L-carnitine concentration increases (as after high-dose intravenous or oral administration of L-carnitine), efficiency of reabsorption decreases and clearance increases, resulting in rapid decline of circulating L-carnitine concentration to baseline

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