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452,453 In neurodegenerative diseases, neurotoxic substances from neuronal damage help to activate Drp1-mediated mitochondrial fission in microglia, down-regulate OXPHOS and ATP production with elevated ROS production, meanwhile motivating inflammasome formation

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Through cleavage of dynamic phenylboronic ester bonds under ROS stimulation 62 , the hydrogel demonstrated ROS-sensitive drug release behavior, as evidenced by the 90% cumulative release of D-CuP within 72 h under H 2 O 2 stimulation (Fig

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