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It is evaluated that half of all drug candidates are substrates for the P-gp efflux pump, presenting a reduced potential for systemic penetration to the CNS [7]

Brodsky, M

"Weight loss is a side effect for both medicines, but Ozempic has a bigger effect," Ponder says

In addition, the multivalency of dual- and triple-agonists supports the development of nanocarriers with enhanced avidity, promoting receptor clustering and downstream signaling without requiring increased systemic exposure [99]

HOMER suite was also used to identify overly represented motifs in ChIP-seq data