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Enlarged spleen: thalassemia can cause the spleen to enlarge as it tries to filter out abnormal red blood cells

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10.1016/j.freeradbiomed.2003.11.029 69 LiangL.-P.WaldbaumS.RowleyS.HuangT.-T.DayB

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[74] Fruit and iron were also part of the diet, and it appears that at this point, Minot and Murphy were not quite sure that the liver was a very important factor