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From 12:00 to 18:00 h, we prolonged the sampling interval for saliva samples to once every hour, simultaneously with the urine sample collection

The interaction between vascular ECs and vascular smooth muscle cells occurs directly, through main crosstalk mechanisms: paracrine regulation by bioactive molecules, communication via gap junctions, or information transfer via extracellular vesicles or extracellular matrix (ECM) [36]

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