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Luo J, Bai L, Tao J, Wen Y, Li M, Zhu Y, et al

Studies in the model organism Caenorhabditis elegans have demonstrated that different FOXO isoformsparticularly DAF-16Aexert a significant influence on lifespan extension by activating or repressing specific genes such as gst-20 and srr-4, which either promote or inhibit longevity-associated mechanisms

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doi:10.2307/4583104

The few studies that matched cases with controls did not use a paired method of analysis such as McNemar's test which biases the results towards null