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In another unique multicenter cohort, which included 20 patients with biopsy-confirmed NASH and F2-F3 fibrosis, after treatment with pegozafermin at a dose of 27 mg weekly for 20 weeks, an improvement 2 points in the NAFLD activity score (NAS) with 1 point in ballooning or lobular inflammation, and without worsening of fibrosis, was observed in 63% of patients, with a marked reduction in hepatic fat by MRI-PDFF (64.7%

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