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Thus, amendment methods such as membrane engineering or removal of immunogenic components can mitigate immune reactions and improve the vesicles immunomodulatory properties [241]

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LC, a known agonist of mitochondrial function, is a neuronal growth factor with antioxidant effects on central nervous system neurons, and plays an important role in the transport of long-chain fatty acids into mitochondria [191]

doi: 10.5187/jast.2023.e29 22 Payan-CarreiraR

There are reports of beneficial changes in the gut microbiota by biguanides, but few other anti-diabetic drugs are reported 6,7,8