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74 The difference in regard to visceral, hepatic adiposity, hypoadiponectinemia, the insulin-sensitizing hormone-adiponectin, resting energy expenditure, 67,75,76 lipid metabolism 77 may also contribute to higher IR in male compared with female

The understanding that obesity is a polygenic disease is well-established, with leptin (LEP), leptin receptor (LEPR), melanocortin 4 receptor (MC4R), and proopiomelanocortin (POMC) being prominent contributors