Unlike genetic resistance, these phenotypes enable fungal cells to survive high concentrations of antifungals without a measurable increase in minimum inhibitory concentration (MIC), contributing to chronic and relapsing infections ( Cryptococcus can enter a quiescent state that confers high tolerance to AmB (Ke et al., 2024)
This individualized focus is key, especially since many patients stop GLP-1 treatments due to poorly managed side effects
Phentermine/topiramate (Qsymia) is taken once daily
For those using GLP-1 medications for weight management, reduced efficacy may manifest as weight loss plateau or regain
Calhoun CA, Lattouf C, Lewis V, Barrientos H, Donaldson ST
What are the known side effects documented in bpc 157 and tb 500 side effects reddit posts