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Abbreviations ADA: American Diabetes Association BMI: Body Mass Index Cis: Confidence Intervals CNKI: Chinese database China National Knowledge Internet DBP: Diastolic Blood Pressure DDP-4: Dipeptidylpeptidase-4 DIC: Deviance Information Criterion EASD: European Association for the Study of Diabetes EBID: Twice-daily Exenatide EQW: Once-weekly Exenatide FDA: Food and Drug Administration FPG: Fasting Plasma Glucose GIP: Glucose-dependent Insulinotropic Polypeptide GLP-1: Glucagon-like Peptide GLP-1 RAs: Glucagon-like Peptide Receptor Agonists HbA1-c: Glycosylated Hemoglobin, Type A1C HDL-C: High-Density Lipoprotein Cholesterol LDL-C: Low-Density Lipoprotein Cholesterol MD: Mean Difference NMA: Network Meta-analysis OR: Odds ratio RCT: Randomized Controlled Trail RR: Relative Ratio SBP: Systolic Blood Pressure SD: Standard Deviation SE: Standard Error SGLT-2: Sodium-dependent Glucose Transporter 2 SUCRA: Surface Under the Cumulative Ranking Curve T2DM: Type II Diabetes Mellitus TC: Total Cholesterol References Tao, Y

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Nutritional support Polly does not provide nutrition coaching, meal plans, or dietary guidance

An onboard thermometer allows the operator to monitor and adjust the temperature of the treatment to ensure the procedure is comfortable

shot of hard liquor (40% alcohol) One-third jigger (.5 oz.) of Everclear (95% alcohol) More Than One Standard Drink One 16 oz

Most patients undergo the procedure using local anesthesia, which reduces risks and recovery time over general anesthesia