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Nucleic acid-based therapy for brain cancer: challenges and strategies

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In the control group, saline (0.3 cc, 0.9%) was administered intraperitoneally 45 min post-midline laparotomy, which was the sole surgical intervention

Oxidative stress is known to impair nitric oxide (NO) bioavailability, which in turn modulates norepinephrine (NE) activity

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Some studies have reported age-associated increase in oxidative stressled ROS as a contributor to formation of neuronal plaque, - synuclein, and mHtt (Li et al., 2013), and other studies have suggested a role for amyloid protein formation in ROS production (Behl et al., 1997