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The human GLP-1R was modified with its native signal sequence (M1-P23) replaced by the HA signal peptide to facilitate receptor expression

Quick Answer: GLP-1 works in the brain by binding to GLP-1 receptors distributed across multiple regions, triggering signalling cascades that suppress appetite, influence reward processing, and may protect neurons from damage

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While heterogeneity and limited study numbers warrant caution, these results highlight GLP-1RAs as promising candidates for AUD management

Carnitine deficiency can occur when the body is unable to absorb or obtain enough carnitine from food, leading to symptoms such as weakness in muscles, fatigue, irritability, and delayed movement development