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Berardis DD, Orsolini L, Iasevoli F, Tomasetti C, Mazza M, Valchera A, et al

In endometriotic cells, ferroptosis resistance mechanisms are up-regulated, including increased expression of GPx4 and GSH, and fibulin 1 (FBLN1) which inhibits ferroptosis, thereby promoting cell survival and lesion progression

The BBB is a major obstacle for many drugs, especially large molecules like peptides, in reaching the central nervous system

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Although it entered phase 1 trials in consideration as a treatment of ulcerative colitis, it has not been approved by the US Food and Drug Administration (FDA) for medical use, and data on human subjects is lacking

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