Oncol Lett (2017) 13(2):5438
WADA and Athletic Bans MOTSc falls under WADAs Prohibited List , category S2 Classified alongside peptide hormones, growth factors, and related substances Banned in- and out-of-competition Positive tests may result in disqualification or suspension WADA prohibits all synthetic analogues of mitochondrial and peptide growth factors, including MOTS-c. World Anti-Doping Agency, Prohibited List Global Legal Overview Canada, UK, Australia : MOTSc is legal for research but not human use EU : Generally treated the same as RUO peptides
Strategies to improve plasma half life time of peptide and protein drugs
10.1016/S0022-2143(00)70020-5 J
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Elevated 27HC levels in hepatocellular carcinoma cells upregulate glutathione peroxidase 4 (GPX4), leading to ferroptosis resistance and promoting cancer proliferation ( Transforming growth factor 1 (TGF-1) secreted by cancer-associated fibroblasts (CAFs) activates JUN signaling in hepatocellular carcinoma cells, leading to increased semaphorin-3C (SEMA3C) expression