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A previous CB1 receptor blocker, Rimonabant, was approved in Europe in 2006 but was discontinued in 2008 owing to serious psychiatric side effects

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However, it is important to note that these studies are still limited, and more research is needed to fully understand how safe and effective this combination is for long-term weight loss

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Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal

Tirzepatide (Mounjaro & Zepbound Eli Lilly) Mounjaro : Approved for diabetes