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Consistent with this, expression levels of the long noncoding RNA, maternally expressed 3 ( MEG3 ) and glucose transporter 2 ( SLC2A2 ), both of which contribute to insulin synthesis and secretion (4346), increased in a step-wise fashion from the -1 to -4 subclusters (Figure 3D)

However, this multi-receptor agonism approach to weight loss was hindered by commercial considerations of production and formulation [45], the biological impasse that glucagon potently induces hyperglycemia [56,57], and potential dose-limiting cardiovascular liabilities arising from positive chronotropic actions to influence hemodynamic parameters [58]

Eugster, E

Aust, M

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10.1016/j.biopha.2017.06.010 Biomed