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This enterokine reaches the liver via the enterohepatic circulation, where it binds to the fibroblast growth factor receptor 4 (FGFR4)

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The administration of the peptide achieves the onset of stage 2 sleep, as well as the non-REM phase when the muscles are maximally relaxed, and there are no sudden body movements

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This class of compounds interacts covalently with the catalytically active serine hydroxyl (Ser630) and has a proline-like group that occupies the S1 pocket of the active site