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Kim JY, Hwang HG, Lee JY, Kim M, Kim JY

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Most patients notice improved energy and mood within 48 hours, with many choosing to come in weekly for ongoing support

A Japanese clinical review showed significant electrophysiological improvement in neuropathy patients treated with methylcobalamin (Tokuda et al., 2018)

These findings reveal a brain-gut circuit underlying opioid-induced constipation and suggest potential therapeutic strategies to mitigate this debilitating side effect