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Specifically, the generation of ceramides by dihydroceramide desaturase 1 (DES1) in adipocytes seems to impart some of the lipotoxic effects such as impaired glucose utilization, insulin resistance and hepatic steatosis (198)

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Changes in the ratio of cortical R2* and medullary R2* also did not vary significantly between SGLT2 inhibitor users and nonusers in both semaglutide and placebo groups ( P -interaction=0.88 and P -interaction=0.84, respectively)

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