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Therefore, compounds inhibiting the accumulation of senescent cells have become the subject of intensive research, especially for their potential application in treating diseases such as ischemic heart disease, Alzheimers disease, diabetes, atherosclerosis, or degenerative joint disease [98]

ACPs are structurally classified into 4 different groups, including alpha (), beta (), alpha-beta (), and non-alpha-beta (non-)

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Rapid or significant calorie restriction, especially if nutritionally unbalanced, may result in inadequate intake of essential minerals and vitamins