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Only Melanotan 1 (afamelanotide) has received regulatory approval for erythropoietic protoporphyria (EPP) on the basis of phase III RCT data

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Clinical Features Melanocytic activation Constitutional Racial melanonychia It is commonly encountered in skin phototypes IV, V, and VI, that is, darkly pigmented races including Blacks, Asians, Middle-East, and Hispanics.[11] The incidence reportedly varies from 1% in whites, 10%20% in Japanese and Asians, and 77100% in African Americans.[7] Racial melanonychia is more common in fingers (thumb, index finger), generally involves multiple nails [Figure 5] and the band width increasing with age