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However, gastrointestinal side effects were more common among orforglipron users, highlighting the need for further research to ensure its safety and effectiveness in patients with severe gastrointestinal disease and issues related to the gastrointestinal tract

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Start your intake Retatrutide vs orforglipron what you actually need to know in 2026 Both drugs are Eli Lilly assets, both target the GLP-1 axis, and both are still in the regulatory pipeline