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Ongoing evaluation by your healthcare provider will determine the duration of treatment based on your progress and health status

Some clear triggers to stop and contact a clinician include: New or worsening hypothyroid symptoms or an unexpected rise in TSH Unexplained INR instability if you are on warfarin New seizures or increased seizure frequency Evidence gaps and how clinicians can manage uncertainty Large randomized trials of supplement-drug interactions are rare

Once tolerated, the dose can be gradually increasedor heldunder the supervision of your provider

Animal reproduction studies in rats and rabbits showed fetal developmental effects at high doses, prompting a pregnancy category classification requiring discontinuation before conception