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Conclusion: Our study findings provide a comprehensive metabolomic knowledge base and other soluble biomarkers for a better understanding of the pathophysiology of LC and suggests sarcosine and serine supplementations might have potential therapeutic implications in LC patients

This is the dose used in clinical settings and has been shown to effectively increase IGF-1 levels without significant suppression of endogenous growth hormone

In addition, OAT induces proline dehydrogenase (PRODH), leading to mitochondrial ROS production, which further amplifies TGF-1 signaling and tissue fibrosis [71]