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246 In a meta-analysis of 14 randomized controlled trials including 766 participants, green coffee extract at dosages ranging from 90 to 6,000 mg/day (providing 13.5 to 1,200 mg/day CGA) for up to 16 weeks lowered serum total cholesterol

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For instance, in the SELECT trial, nearly 30% of participants discontinued semaglutide, while real-world estimates suggest discontinuation rates between 50% and 75% at 12 months[79]

Most of the studies have shown its therapeutic role in melasma, whereas some studies have contradicted this fact[] [Table 1]

Clinical trials show an average weight loss of about 4% of your starting body weight after just four weeks

When applied topically you can target the affected area for anti-inflammatory effects and systemic absorption