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Previous small trials of angioplasty/stenting demonstrated safety/feasibility in selected patients, but more data on prognosis without intervention on current best medical treatment are required to inform the need of future trials

The results from organoids were also compared with publicly available single-nucleus RNA sequencing (snRNA-seq) datasets from AD patients (GSE157827 and GSE174367) for cross-validation and identification of commonly affected genes

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Jastreboff et al., 2022) documented superior weight loss and glycemic control compared to single-target GLP-1 agonists, with up to 22.5% body weight reduction at 72 weeks in the SURMOUNT-1 trial

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