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In a complementary approach, Jiang et al
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Activation of AMPK prevents the polarization of pro-inflammatory macrophages (M1) triggered by lipopolysaccharide, thereby reducing inflammation and subsequently improving insulin resistance
Hyperactivated M1 alveolar macrophages are taken over by SARS-CoV-2 allowing for viral infection and spread, while M2 alveolar macrophages can degrade the virus and limit its spread (Knoll et al., 2021
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