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For example, excessive ER stress stimulates apoptosis via the ATF6-CHOP pathway in human renal TECs under ischaemiareperfusion injury-induced AKI conditions 13

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doi: 10.1371/journal.pone.0023789 10 BouterC.HennigesP.FrankeT

In line with this is an important concept in the study of G protein-coupled receptors (GPCRs): the idea of receptor oligomerization, in which GPCRs interact with other GPCRs in close proximity, resulting in physical association with possible conformational changes as well as changes in intracellular signaling and/or ligand binding