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Alterations of the predominant fecal microbiota and disruption of the gut mucosal barrier in patients with early-stage colorectal cancer

doi: 10.1016/j.adolescence.2014.05.012 180 AminNLiuJBonnechereBMahmoudianDehkordiSArnoldMBatraRet al

Spiegel R, Kalla R, Mantokoudis G, Maire R, Mueller H, Hoerr R, Ihl R

Overcoming implementation challenges of personalized cancer therapy

& Lynch, R

Thus, GSH participates as a co-factor in several reactions, including the elimination of peroxides by GSH peroxidases (GPx), the covalent addition to protein cysteines (Protein-SSG) predominantly performed by glutaredoxin, and the detoxification of electrophiles by S-glutathionylation (GS-R) formation as catalyzed by the enzymes glutaredoxin and glutathione S-transferase (GST) [4,11,12]