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Phase 2 trials showed up to 24% body weight reduction at the highest dose, and Phase 3 data from the TRIUMPH program pushed that number even higher, reaching 28.7% in participants with obesity and knee osteoarthritis

Brunetti-Pierri N, Clarke C, Mane V, Palmer DJ, Lanpher B, Sun Q, OBrien W, Lee B (2008) Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors

The therapeutic limitations of single-target agents in MASLD underscore the need for multi-target approaches, such as palmatine