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Starting at 0.5 mg is common for patients who were on lower tirzepatide doses (5-7.5 mg), while 1.0 mg is typical for those coming from 10-15 mg tirzepatide

Khan MAB, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J

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While these increases have not been associated with increased cardiovascular events in trials to date, the FDA label for Zepbound recommends heart rate monitoring, particularly in patients with cardiac disease

In our experience, it can be marginally effective in some cases

14.9% Mean body weight reduction STEP-1 trial 68 weeks 68 weeks Typical protocol length Titration + maintenance ~85% Patients who reach a measurable weight delta By week 12 lab review PROTOCOL TIMELINE Week 4 Appetite signaling shifts First meaningful behavior change