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Published evidence indicates that B12 deficiency can make HbA1c unreliable, but the direction of the distortion whether the result is spuriously high or spuriously low is variable and may depend on the degree of anaemia, the specific HbA1c assay used, and other concurrent conditions

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found that T2DM was associated with a significantly higher risk of hepatic decompensation (hazard ratio 3.29, 95 % confidence interval 2.21-4.90) and new-onset HCC (hazard ratio 7.72, 95 % confidence interval 2.61-22.87) over a median follow-up of 2.8 years, even after adjusting for risk factors and other potential confounders, including baseline liver stiffness measured by magnetic resonance elastography (Huang et al., 2023[31])

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Dyslipidemia plays a fundamental role in CVD development and clinical studies have established a causal association between elevated levels of LDL-C and an increased risk of atherosclerotic CVD 3

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