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This section is offered to provide clinicians and patients with a framework and strategy for determining optimal treatment approaches (see Figure 1)

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Acknowledgments We thank Giorgos Kastellakis for helpful comments on the manuscript

These signal molecules are synthesized by your body every day to enable communication between tissues

This study was limited to the subgroup of patients with prediabetes with the primary aim to assess the proportion of individuals who developed T2D 18