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The citrate synthase reaction is often considered the rate-limiting step of the TCA cycle due to the large free energy change of the reaction

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[DOI] [PubMed] [Google Scholar] 36.Grant A., Ponia S.S., Tripathi S., Balasubramaniam V., Miorin L., Sourisseau M., Schwarz M.C., Snchez-Seco M.P., Evans M.J., Best S.M., et al

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