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The article was updated on 3/6/2026.

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Recent research has identified several adaptive mechanisms through which red blood cells regulate oxygen delivery, including NO-driven changes in membrane deformability, Cys93-dependent S-nitrosylation, adenosine-mediated stimulation of glycolysis and 2,3-BPG production, and the formation of hypoxic memory via degradation of eENT1 ( Beyond their role in gas exchange, erythrocytes participate in a wide range of metabolic and signaling processes

A 2025 post-hoc analysis of the SURMOUNT clinical trials, conducted by researchers at NewYork-Presbyterian and Weill Cornell Medicine, examined results from 2,542 women across premenopausal, perimenopausal, and postmenopausal stages