Minich T, Riemer J, Schulz JB, Wielinga P, Wijnholds J, Dringen R
The researchers randomized the patients into three groups: once-daily semaglutide, liraglutide, or placebo in one of four volume-matched doses (semaglutide 0.05, 0.1, 0.2, or 0.3 mg and liraglutide 0.3, 0.6, 1.2, or 1.8 mg, with both compared within each volume-matched dose group)
Active ARG1 exerts dual tumor-promoting effects: first, it directly depletes arginine essential for T cell activation in the microenvironment, leading to T cell functional suppression or even apoptosis
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to clarify and it is plain the investigators were comfortable with this explanation
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