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Impaired methylation reduces SAM-e, directly reducing COMT, HNMT, TPMT, and AS3MT activity

Lancet (2005) 366:21127.10.1016/S0140-6736(05)67889-0 4 ClarkCM

423 The study began by inducing inflammation in mice through the injection of various Toll-like receptor (TLR) agonists and then assessed the inflammation by measuring plasma tumor necrosis factor-alpha (TNF-) levels

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0.6 mmol Hcy/g body weight in the third week) compared to the control group [53]

In severe cases, patients may experience long-term disability, reduced range of motion, or ongoing neurological symptoms