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J Anal At Spectrom

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The results from several in vitro and in vivo studies suggest that long-term exposure to GH may induce insulin resistance by several mechanisms, including increased expression of cellular proteins that inhibit the insulin receptor signaling [2930], a decrease in the expression of several key proteins involved in carbohydrate metabolism, as well as a decrease in the insulin-mediated activation of glycogen synthase in the liver and muscle [31]

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