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Thus, clinical trials can be conducted using topical or oral routes of administration to avoid high systemic exposure to the drug or compound under investigation [127]

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This work was supported by the National Health and Medical Research Council (NHMRC) of Australia, through grants APP1103689 and APP1122484 to LEW, DAS and HAH, APP1139763 to RBG, LEW and KAW, a Career Development Fellowship to LEW (APP1127821) and Senior Research and Investigator Fellowships to RBG (APP1117538 and APP2009940)

Through its regulation of tight junctions, larazotide can help to reduce the number of inflammatory particles that cross from the intestinal lumen (where food is) into the body

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Another trial (NCT05586360) is exploring whether oral simvastatin can mitigate YAP-mediated Treg dysfunction in prostate cancer, shedding light on potential mechanisms