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In studies on mice and rats, high dose levels of dichlorvos (a single dose of 40 mg/kg body weight or multiple doses of 5 or 10 mg/kg body weight) induced disturbances in spermatogenesis, characterized by damage to the seminiferous tubules and Sertoli cells and by hypertrophy and increase in the number of Leydig cells

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At excessive concentrations, breakdown may exceed synthesis

The applications of GLP-1RAs extend far beyond diabetes management