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In November 2024, Novo Nordisk AS is expected to secure expanded FDA approval for CagriSema, its dual amylin/GLP-1 agonist, for a broader population of patients with type 2 diabetes and high cardiovascular risk

NICE guidance supports this stepwise approach, adding a GLP-1 agonist to metformin when further glycemic control or additional protective benefit is required, rather than routinely replacing one with the other

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doi: 10.3389/fphys.2018.00477 27 XuJet al

These observations may be explained by limited statistical power due to very low event numbers, as well as competing mental health risk factors in older adults

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