Furthermore, a similar trend applies to acid solvation: p K a increases roughly linearly with stronger solvation of the conjugate base product (e.g., A ) and easier desolvation of the acid reactant (e.g., HA
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Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig
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