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Increased levels of SDF-1 are associated with increased severity of coronary artery obstructions [21], and high levels of the chemokine are seen in patients with an acute coronary syndrome and forebode a worse prognosis and an increased risk of heart failure [22,23,24]

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MTX-N-ISG surpassed the drug level in the brain compared to MTX-ISG and MTX-N, which showed a more significant proportion of the drug in the brain than free MTX

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