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As a start, you can: wear wide-brimmed hats when you go outside use lip balm with SPF limit your exposure to direct sunlight While lip freckles are normal and typically harmless, there are a handful of options you can pursue if youd like to remove them for either cosmetic or preventive reasons

(14) The mechanisms underlying this potential action might involve IGF-1-mediated suppression of muscle cell-specific enzymes referred to as E3 ubiquitin ligases, including atrogin-1 and muscle ring finger protein-1 (MuRF1)