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The antidepressant-like effects were proposed to result from direct activation of the AMPK signaling pathway, leading to enhanced serotonergic neurotransmission [66]
J Biol Chem 285:3180631818 Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
10.1016/j.devcel.2024.06.018 69 LeJ.KonN.LiT.WangS.-J.SuT.HibshooshH.et al (2015)
Metabolic and systemic side effects Beyond the GI tract and injection site, cagrilintide can produce effects that ripple through multiple body systems
Hormonal Fluctuations: Many women experience fluid retention around their menstrual cycle