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Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults with Overweight or Obesity: The STEP 4 Randomized Clinical Trial

Versatile Across Experimental Designs : Researchers use the combination in protocols that track outcomes such as body weight, energy intake, glycemic measures, blood pressure, and other cardiometabolic markers (model-dependent)

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Many people also report that foods high in fat or sugar become less appealing, a separate brain-level effect that further supports sustainable weight loss without the psychological strain of traditional calorie counting

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